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  • The Food and Drug Administration, FDA, has approved the drug Vivitrol for that treatment of opioid dependence as outlined by a news release by them on 10-12-2010. Using two separate drugs to shed weight can be very effective you'll find combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the people that go through it you should err on the side of caution and permit the FDA do its job and demand some research be done so the public recognizes the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies come in business to generate money and that they would say almost anything to keep people on his or her medications. Researchers found out that participants taking this drug to get a year, dropped a few pounds within a month and have kept the weight off throughout the 56 weeks of the study. Contrave is really a combination with the drugs naltrexone and bupropion, which seems to reflect a fresh trend of weight-loss drugs that are made up of many active ingredient, which might make them more potent and safer. Combo-pilling is the newest fad or in addition to this the newest ahead under scrutiny and therefore it is just more publicly known in recent months, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is now popular may be the fact that at the time of right now there aren't any long term prescription weight loss supplements that have been authorized by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations are already rejected or have yet to be authorized by the FDA. Seizures really are a side effect with Contrave and mustn't be taken in those with seizure disorders. The drug also can raise blood pressure levels and heartrate, and shouldn't be used in people with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure and pulse rate and must not be used in patients with uncontrolled high blood pressure, as well as by a person with heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients using a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients for the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking. Suboxone consists of two drugs; buprenorphine and naloxone. The naloxone is irrelevant when the addict uses the medication properly, but when the tablet is dissolved in water and injected the naloxone can cause instant withdrawal. When suboxone is employed correctly, the naloxone is destroyed within the liver right after uptake in the intestines and contains no therapeutic effect. Buprenorphine is the active substance; it can be absorbed within the tongue (and through the entire mouth) but destroyed through the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I purchased this formulation if the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have also treated addicts who may have had gastric bypass, in which the first area of the intestine is bypassed along with the stomach contents empty right into a more distal area of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the task with normal anatomy the place that the drug is taken up through the duodenum and transferred straight away to the liver with the portal vein, where it can be quickly and completely destroyed. After gastric bypass naloxone can be taken up by areas of the intestine which aren't served with the portal system, causing blood amounts of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.

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